She portrays an older woman who dates a man in his 20s. Drescher herself dated a man 16 years her junior for four years.
One episode echoes a scene where her boyfriend's father and stepmother came over for a visit and the stepmom was two years younger than Drescher. She rifled through her closet to find something tie-dyed to look younger.
In another show, Drescher learns that the live-in boyfriend is secretly hanging on to his old apartment in case something goes wrong.
"In the series, eventually he gives up the apartment by the end of the episode because our love is true," she told reporters Saturday. "In real life, he kept the apartment and now he's back in it."