By the time he died, Christopher Reeve (search) had at last "escaped the cape" — he had become bigger than the Superman character he portrayed on screen.
Reeve championed cutting-edge research into spinal cord injury, offering himself as a guinea pig for new therapies and vowing he would one day walk again. He never did. But his dream is now a plausible one for thousands of others who are paralyzed.
"The biggest hope is in biological research to allow the spinal cord to heal itself and even regenerate. That's just over the horizon but closer than ever before. Most people feel within the next 10 to 15 years, somewhere within our lifetimes," said Dr. Jack Ziegler, president of the American Spinal Injury Association (search).
Some even thought it would come in time for Reeve.
"I thought it was going to happen," said Dr. Doug Kerr, a Johns Hopkins University neurologist who works with stem cells (search) — controversial research that Reeve advocated with superhuman strength even as he wheezed through a respirator from his wheelchair.
"It was Star Wars science fiction, this concept of rewiring the nervous system," but Reeve "thrust this field forward by leaps and bounds," Kerr said.
Reeve died Sunday after developing a serious bloodstream infection from a bedsore, a common problem for paralyzed people. He went into cardiac arrest Saturday at his home in Pound Ridge, N.Y., then fell into a coma, dying the next day at a hospital. His wife, Dana, and other family members were with him.
As an actor and a man, Reeve embodied strength and athleticism and performed his own movie stunts, including his 1978 starring role as Superman. It made him famous but he longed to, as he often put it, "escape the cape" and take on other characters. He played a crippled Vietnam veteran in the Broadway play "Fifth of July," a lovestruck time-traveler in the movie "Somewhere in Time," and an aspiring playwright in the suspense "Deathtrap."
But real life — not a movie — gave him the best opportunity to shed the cape and show extraordinary human powers. Reeve suffered one of the most severe spinal injuries possible when he was thrown from his horse and broke his neck during an equestrian competition in May 1995.
Aided by access to the best medical care available, Reeve endured years of therapy to allow him to breathe for longer periods without a respirator while tenaciously seeking a cure that would allow him to walk again.
"I refuse to allow a disability to determine how I live my life. I don't mean to be reckless, but setting a goal that seems a bit daunting actually is very helpful toward recovery," he said.
He sparked hope even in many skeptics in 2000, when he was able to move an index finger. Motivated by success, he thrust himself even harder into workouts to strengthen his legs and arms. Electrical stimulation of his muscles allowed him to regain sensation in some other parts of his body.
Treatments advanced, too. Improvements in surgical techniques helped stabilize the spine more, and electrical stimulation and exercise therapy have helped many, according to Ziegler.
As Reeve transformed his body, he morphed into an advocate, first for better benefits for people with long-term disabilities, and then for science to help the 250,000 Americans who suffer paralysis. The Christopher Reeve Paralysis Foundation has given $40 million to spinal cord research since he merged it with the American Paralysis Foundation in 1999.
Some of that has been for embryonic stem cell research, a promising but contentious field of medicine that the Bush administration has severely restricted because it involves destroying embryos. Scientists think these early, all-purpose cells can be coaxed to form nerves and specialized tissues to repair a host of woes.
Reeve and fellow actor Michael J. Fox, who has Parkinson's disease, have helped make stem cells a major campaign issue between President Bush and Sen. John Kerry. Kerry even mentioned Reeve during the second presidential debate on Friday and praised him Monday in remarks before a speech in Santa Fe, N.M.
"He was an inspiration to all of us and gave hope to millions of Americans who are counting on lifesaving cures that science and research can provide," Kerry said. "In part because of his work, millions will one day walk again."
At Hopkins, research a few years ago demonstrated that stem cells could allow paralyzed mice and rats to do just that.
"This is one of the most difficult tasks you can ask a stem cell to do — to rewire, to extend axons and to form new connections at great distances to restore function," said Kerr. "We're clearly getting there."
Reeve "appropriately brought a sense of urgency to this issue," said Daniel Perry, president of the Coalition for the Advancement of Medical Research, a stem cell advocacy organization. "On Capitol Hill he was such a highly regarded figure and was so focused on the message."
A research center on paralytic spinal cord injuries, the Reeve-Irvine Research Center, was established in Reeve's name at the University of California, Irvine.
"He was such an immense personality, such a force in the field," said Dr. Oswald Stewart, the center's director. "He created an enthusiasm for what we do in the lab."
Reeve also reached out to people beyond those with spinal cord injuries.
"He was able to inspire hope in patients with diabetes, Alzheimer's, cancer, Parkinson's disease, Lou Gehrig's disease ... tragic and life-threatening conditions that face tens of millions of Americans," Perry said.
But Reeve's real legacy is more than dollars and advocacy, many said. It's the hope that fewer diseases in the future will be called incurable.
"He put a human face on the dreams," Perry said. "He used his star power as a celebrity for a great good that transcends anything that most of us will ever achieve."
Before Reeve, if someone had a spinal cord injury, "there was really no hope," said Dr. John McDonald, who was a researcher at Washington University in St. Louis when he devised the exercise and therapy regimen that allowed Reeve to recover limited feeling and movement.
"He's changed all that," said McDonald, who is now at Johns Hopkins University's Kennedy Krieger Institute. "He's demonstrated that there is hope and that there are things that can be done."