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Tonight on "Hannity & Colmes" ...

• John Edwards (search) has challenged Democratic front-runner John Kerry (search) to a one-on-one debate in a nomination contest that is finally down to a two-man race.

Tony Blankley of the Washington Times and former Arizona Sen. Dennis Deconcini join the political debate.

• Keep your friends close ... but your enemies closer? Martha Stewart (search ) may say to heck with all of them!

Wait until you hear what Stewart's close friend Mariana Pasternak (search) had to say when she took the stand. Will it be very damaging to the defense of the domestic diva?

Criminal defense attorney Melinda McAllister and former federal prosecutor Tim Susanin assess the situation.

• The search continues for Michael and Rebecca Hargon (search ) and their 4-year-old son, Patrick. They have been missing since Saturday.

The FBI has joined local authorities and the Mississippi Highway Patrol in investigating the disappearance. Are they any closer to finding out what happened? Any new clues?

We'll get a LIVE search update from bloodhound handler Joe Canfield and Crime Stoppers State Director Margaret Cooper .

How can an entire family vanish? How far should search efforts spread? We'll ask former LAPD detective Tom Lange.

All these stories and much more!

Don't miss "Hannity & Colmes" LIVE this evening at 9 p.m. ET!