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Tonight on "Hannity & Colmes" ...

• Michael and Rebecca Hargon (search) and their 4-year-old son, Patrick, have been missing since Saturday. The FBI has joined local authorities and the Mississippi Highway Patrol in investigating the disappearance. What happened?

Relatives are offering a reward for the Hargons' safe return. Rebecca's parents, William and Linda Hirtz, will join us.

• San Francisco's mayor says same-sex nuptials will go on, at least until Friday when a judge may rule to nullify them all. Are the marriages legal? Does this mayor think he is above the law?

The city of San Francisco may be defying state law — So, why would the city be suing the state? Should it be the other way around?

California State Assemblyman Mark Leno and Randy Thomasson, executive director of Campaign for California Families, join the debate.

• Is it still the economy, stupid?

Jobs and trade take center stage on the Democratic presidential campaign trail — Front-runner John Kerry (search) wins a huge labor endorsement — But White House hopeful John Edwards (search ) does not seem worried.

What clout — if any — does the labor endorsement have on the Democratic trail? Former Reps. Tony Coelho and J.C. Watts weigh in.

Meanwhile President Bush (search) says the economy is growing and getting stronger.  John  Podhoretz, author of "Bush Country : How Dubya Became a Great President While Driving Liberals Insane," agrees ... and he'll tell us why.

• What exactly is the situation on the ground in Iraq? How big of a challenge will it be root out insurgents and institute order? FNC's own Geraldo Rivera will update us LIVE from Iraq.

All these stories and much more!

Don't miss "Hannity & Colmes" LIVE this evening at 9 p.m. ET!