Flu shot (search) makers said their supply is depleted, thanks to an overwhelming vaccine demand prompted by a particularly bad early flu season. The flu has already killed at least 11 children across the country.

Chiron (search) and Aventis Pasteur (search) together made about 80 million doses of the injected vaccine, which ordinarily would be enough to take care of U.S. demand.

"Because of the recent outbreak, we've seen an unprecedented surge of vaccine orders late in the season," said Len Lavenda, an Aventis spokesman. "As a result, we have now shipped all our available supplies."

"It's all been shipped out," said Chiron's John Gallagher. "We began shipping in August. It's all gone at this point."

The companies said they cannot make more vaccine this year, because the process takes four months. By that time, the flu season would be over.

Nevertheless, the companies said people who have put off getting their shots may still be able to find them, since distributors and doctors' offices may still have some left.

Another alternative is the FluMist, the more expensive inhaled version of the vaccine. Its maker, MedImmune Vaccines, made between 4 million and 5 million doses this year. Spokeswoman Jamie Lacey said that as of Nov. 18, the company had sold 400,000 doses, and "there is still a wide supply available."

The nasal spray is recommended only for healthy people ages 5-49, and disease doctors are suggesting it as an option to save the traditional vaccine for more at-risk people.

The Centers for Disease Control and Prevention (search) said that in a typical year, between 70 million and 75 million Americans get flu shots, and the record is 80 million.

Dr. Julie Gerberding, the CDC head, said that this year more people than usual got the shots in October and November, and there is unusually high interest in December.

The CDC said it is not unusual for supplies to run short this time of year, as health care providers stop giving vaccinations. The agency said it is working to locate supplies that can be sent where they are needed.

"What we are telling people is there is still vaccine in the pipeline, although we are not sure how much," Lavenda said. "People who want to get a flu shot this year should not wait any longer. They will have to be persistent."

In Colorado's El Paso County, health director Rosemary Bakes-Martin said her agency hoped to order 2,000 doses this week but could come up with just 500 from suppliers.

"The story they're telling us is that they weren't expecting this shortage, that they were hit with increased orders in the last week," she said.

In a typical year 36,000 Americans die from the influenza virus, but flu researchers expect a higher death toll this year.

The sudden late demand for flu shots was triggered by reports of an especially bad flu season, especially for children.

The outbreak was particularly intense in Colorado, where within the past month, more than 6,300 people have been infected and at least six have died. All the dead were under 16 years old.

And at least three children in Texas and one each in Oklahoma and New Mexico have already died from the flu.

Colorado is one of 10 states with a widespread flu outbreak, the highest designation given by the CDC. The others are Texas, Washington, Idaho, Nevada, Utah, New Mexico, Arkansas, Tennessee and Pennsylvania.

Health officials in several of those states said there were still flu shots available, but they were fast disappearing.

"We will run out," said Ann Wright, spokeswoman for the state health department in Arkansas, but officials don't know when.

Even before this year's deaths, there were signs this could be a bad flu season. Some parts of the country were hit hard a month earlier than usual, and doctors are seeing the A-Fujian-H3N2 strain, part of a class of flu viruses that caused severe outbreaks in the United States in the 1990s.

Even though health officials urge people to get their shots, it is still not clear how effective they will be against this strain, which is somewhat different from the three that this year's vaccine is designed to combat.

The Associated Press contributed to this report.