Tonight on Special Report with Brit Hume:

While Saturday's crash of the Columbia space shuttle was undoubtedly a tragedy, U.S. leaders said it in no way will slow the advancements being made in space exploration and science.

However, questions are swirling over how NASA is going to get over the latest disaster in its shuttle program. We'll have a complete report on the fallout.

Plus:

• Plus, President Bush sent his $2.23 trillion 2004 budget to Capitol Hill Monday morning, including a proposed 3 percent increase in NASA funding. But will the budget make it through Congress unchanged?

• And Pres. Bush goes to the National Institutes of Health to discuss his BioShield initiative. In his State of the Union Address, President Bush announced Project BioShield -- a comprehensive effort to develop and make available modern, effective drugs and vaccines to protect against attack by biological and chemical weapons or other dangerous pathogens.

All that plus, is there a lack of enthusiasm from the American public toward the space program? We'll ask syndicated columnist and FOX News contributor Charles Krauthammer.

Details on these stories and more on Special Report with Brit Hume.
— Guests and topics are subject to change