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American, Britons Win Nobel Prize for Gene Discoveries

An American and two Britons won this year's Nobel Prize in medicine Monday for discoveries about how genes regulate organ growth and a process of programmed cell suicide. Their findings shed light on the development of many illnesses, including AIDS and strokes.

Britons Sydney Brenner, 75, and John E. Sulston, 60, and American H. Robert Horvitz, 55, shared the prize, worth about $1 million.

Working with tiny worms, the laureates identified key genes regulating organ development and programmed cell death, a necessary process for pruning excess cells. Many cancer treatment strategies are now aimed at stimulating the cell-death process to kill cancerous cells.

Brenner, a professor at the Salk Institute for Biological Studies in San Diego, Calif., is also the founder of the Molecular Sciences Institute in Berkeley. He showed that the tiny transparent worm C. elegans was useful for studying how cells specialize and organs develop. His work "laid the foundation for this year's prize," the awards committee said.

Brenner also demonstrated that a chemical could produce specific genetic mutations in the worm, allowing different mutations to be linked to specific effects on organ development.

Sulston, who is retired from the Wellcome Trust Sanger Institute in Cambridge, England, discovered that certain cells in the developing worm are destined to die through programmed cell death. He described visible steps in the cell-death process and demonstrated the first mutations of genes that participate in that process, the committee said.

Horvitz, of the Massachusetts Institute of Technology, identified the first two "death genes" in the worms and showed that humans have a gene similar to one of them, the awards committee said. Scientists now know that most genes controlling cell death in the worms have counterparts in humans.

Sulston, reached in Cambridge, said he was "surprised and delighted" at winning the prize and emphasized the importance of the work by Brenner and Horvitz. All three had worked together in Cambridge in the 1970s.

"Something we do need to keep in mind all the time is how much can come out of work that's done to try to understand, in the broadest sense, and sharing that understanding with everybody else," he said.

Horvitz was notified by the Nobel committee while vacationing in the French Alps.

"It was quite enjoyable to have champagne before lunch in France," Horvitz said in a telephone call to a news conference at MIT on Monday.

"I would find nothing more gratifying than to learn that one or more of my discoveries led specifically to pharmaceutical treatments and cures for human diseases," he said.

"That's a dream. At this point, I think that dream is still tenable."

Information about programmed cell death has helped scientists understand how some viruses and bacteria invade human cells, the Nobel committee said. In conditions such as AIDS, stroke and heart attack, cells are lost because of excessive cell death. In other diseases like cancer, cell death is reduced, leading to the survival of cells that are normally destined to die.

The award for medicine opened a week of Nobel Prizes that culminates Friday with the prestigious peace prize, the only one revealed in Oslo, Norway.

The physics award will be announced Tuesday and the chemistry and economics awards Wednesday in the Swedish capital.

As in years past, the date for the literature prize has not been set. But it always falls on a Thursday, usually the same week as the other awards.

The award committees make their decisions in deep secrecy and candidates are not publicly revealed for 50 years.

Alfred Nobel, the Swedish industrialist and inventor of dynamite, left only vague guidelines in his will establishing the prizes, first awarded in 1901.

For the prize Monday, he simply stated the winner "shall have made the most important discovery within the domain of physiology or medicine."

The 18 lifetime members of the Swedish Academy who choose the literature laureate make their final decision at one of their weekly meetings, only setting the date early in the same week to keep the world guessing.

Kaj Schueler, a literary editor at Swedish daily newspaper Svenska Dagbladet, predicted the academy's choice would be a surprise since last year's award went to perennial favorite V.S. Naipaul.

"I also think it's time for them to pick a poet," Schueler said, declining to single out any names. "The last poet they had was the Polish writer Wislawa Szymborska in 1996. since they they've had playwrights and prose writers."

The only public hints are for the peace prize.

The five-member awards committee never reveals the candidates, but sometimes those making the nominations announce their choices.

With the world still reeling from last year's Sept. 11 terrorist attacks and concerned about U.S. plans for a war in Iraq, no clear favorites have emerged.

Among the nominees were Afghan President Hamid Karzai, who has sought to unify his country after the hard-line Taliban was ousted by U.S.-led airstrikes, former New York City Mayor Rudolph Giuliani, the Salvation Army and the U.S. Peace Corps.

President Bush and British Prime Minister Tony Blair were nominated for leading the war against terrorism but were seen as unlikely winners in wake of their efforts to convince the world of the need to overthrow Saddam Hussein.

The Nobel Assembly at the world-renowned Karolinska Institute, which selects the medicine prize winner, invites nominations from previous recipients, professors of medicine and other professionals worldwide before whittling down its choices in the fall.

Last year's winners were Leland H. Hartwell of the United States and R. Timothy Hunt and Paul M. Nurse from Britain for discovering key regulators of the process that lets cells divide, which is expected to lead to new cancer treatments.

The awards always are presented on Dec. 10, the anniversary of Nobel's death in 1896.