Tying the Knot of Frasier

Daphne and Niles will finally tie the knot on the opening episode of Frasier this fall.

The Emmy-caliber couple — a sweet-natured British live-in physical therapist and the uptight-but-lovable shrink played by Jane Leeves and David Hyde Pierce — have been shacking up for the better part of two seasons, after years of Niles' harboring a not-so-secret lust for Daphne. 

The big wedding is set to air Sept. 24. 

"There will be wedding bells for Niles and Daphne on the season opener of Frasier, " NBC entertainment president Jeff Zucker confirmed. 

The episode's storyline picks up where last season's cliffhanger season finale left off: with Niles and Daphne on the verge of eloping. 

Frasier, now heading into its 10th season, has won dozens of Emmy awards including in a row as TV's best comedy — a record and more than Cheers, the sitcom it was spunoff from. 

The network declined to give more details about the upcoming nuptials, but it is shaping up as one of those TV events that will be much talked about, widely watched and perhaps ruin the show forever. 

Weddings and babies rarely have helped long-running comedies to sustain their popularity for very long and audiences often dislike to see characters they know and like change. 

Kelsey Grammar, the show's star, has made it no secret that he hopes to carry Frasier on longer than "Cheers," which was on the air for 11 seasons.

For more news, entertainment and sports coverage, click here for NYPost.com.