The Vatican is cross with stars who wear crucifixes as jewelry — and wants stunners like Jennifer Aniston, Catherine Zeta-Jones and Jennifer Lopez to take them off.

The edict from the Vatican news agency Fides slammed the trio and other celebs for turning jewel-encrusted crosses into "the mania of the moment." 

It called the crucifix "sacred" and said using it as a fashion item is outrageous. 

"Crosses glitter around the necks of television show-women, leading models and actresses," the agency raged in a scathing editorial. 

"Jennifer Aniston, star of Friends and wife of Brad Pitt, wears a cross of platinum and diamonds. Naomi Campbell has a collection of enormous, jewel-studded crosses. 

"Catherine Zeta-Jones exhibits a cross of gold and diamonds. This mania is incomprehensible." Also blasted were Cher and Liz Hurley. 

"Is it consistent with the Gospel to spend millions on a copy of the sacred symbol of the Christian faith," the agency asked, "and perhaps forget there are people all over the world who suffer and die of hunger?" 

Cher spokeswoman Liz Rosenberg said: "Why don't you tell the pope to clean up his own house." 

Pricey Manhattan jewelers Harry Winston and Tiffany's don't carry crucifixes, but they do have some big-ticket crosses. 

Winston charges $6,500 to $15,000 for crosses. At Tiffany's, the priciest cross is $20,000.