The Material Girl's black-sheep brother, Martin Ciccone, has not been invited to attend Friday's $2 million bash at Skibo Castle in the Scottish Highlands.
And he's depressed about being left out.
"I'd jump on a plane tomorrow. I don't think my sister realizes how much I love her," Martin, a nightclub DJ, told The Mirror of London.
"It looks like I'll be staying [home]. I'm a casualty of my own life."
Martin has been in and out of rehab centers for alcohol-related offenses, and Madonna is said to be paying for his latest round of treatment at the Chabad Rehabilitation Center in Los Angeles.
Sources told The Mirror the pop goddess is not being mean by refusing Martin an invite — but simply doesn't want to interrupt his therapy.
Martin insists he's not mad.
"I'm not bitter about it. At times, my sister has been good to me. It would be nice to be there on her big day," he said.
However, some patients at the clinic say he's devastated to be missing out on the showbiz wedding of the year.
"He's talked of little else since learning about the wedding. But, like the rest of us, he'll have to watch it on TV," one patient told the paper.
Martin said he has nice thoughts about his sister's big day.
"I hope everything goes well for her. I'll be thinking about them," he said.
As Madonna and fiancé Guy Ritchie arrived at Inverness Airport in Scotland yesterday, they were welcomed by a lone bagpiper playing Scottish folk tunes.
They climbed into a waiting Range Rover with their 4-month-old son, Rocco, and Madonna's 3-year-old daughter, Lourdes, and were whisked away to Skibo in the coastal town of Dornoch.
Hundreds of fans and journalists watched the scene from behind police barricades.
The minister who will marry the glitzy couple in the Scottish castle plans to give them two rolls of toilet paper as a wedding present.
The Rev. Susan Brown said she chose the bizarre gift to remind the pair their marriage should be "soft, strong and very long. It is a symbolic present I like to give to brides I marry."