LOS ANGELES —  Two beautiful doctors, an ornery agent, a cop, a shrink and a cheerleader will help hand out trophies at the Primetime Emmy Awards.

The actors behind these TV roles -- Katherine Heigl, Kate Walsh, Jeremy Piven, Jimmy Smits, Kelsey Grammer and Hayden Panettiere -- are among the presenters set to appear at the 59th Primetime Emmy Awards on Sept. 16, executive producer Ken Ehrlich announced Wednesday.

Other small-screen stars presenting prizes on TV's biggest night include Steve Carell, Kiefer Sutherland, Jon Stewart, Patricia Heaton, Kyle Chandler and the cast of "Entourage": Piven, Adrian Grenier, Kevin Connolly, Kevin Dillon and Jerry Ferrara.

The Primetime Emmy Awards, hosted by Ryan Seacrest, will be broadcast live from the Shrine Auditorium on Fox.