There's an upside to missing out on the Champions League for Liverpool and Chelsea as they occupy the Premier League's top two places.
With no grueling midweek matches in Europe, Chelsea and Liverpool conserved their energy to produce emphatic domestic victories.
A day after Chelsea routed Everton 5-0, Liverpool overwhelmed Watford 6-1 on Sunday to move a point ahead of its London title rival.
Arsenal, Tottenham and Manchester City all failed to win this weekend after playing in the Champions League in midweek. City lost top spot after being held by Middlesbrough on Saturday, while Arsenal and Tottenham drew 1-1 in Sunday's north London derby.
"It's a little physical advantage for sure," Arsenal manager Arsene Wenger said about not playing in the Champions League, which boosts the profits and prestige of participants.
What about the less illustrious Europa League where games are played on Thursday night?
Manchester United followed up its 4-1 victory at Fenerbahce by winning 3-1 at Swansea to halt a four-match winless run in the Premier League. Southampton, though, came back down to earth after beating Inter Milan by losing 2-1 to a Hull side in the bottom three.
LIVERPOOL 6, WATFORD 1
Liverpool occupies top spot for the first time since May 2014 when the team came close to winning the title for the first time since 1990 before a late collapse.
Sadio Mane, Philippe Coutinho and Emre Can scored in the space of 16 first-half minutes to put Watford out of sight. Roberto Firmino, Mane and Georginio Wijnaldum added further goals in the second half.
Liverpool, which has now scored four or more goals in five league matches this season, is a point in front of Chelsea and two ahead of Manchester City and Arsenal.
"On a good day, we are really difficult to play (against)," Liverpool manager Juergen Klopp said.
SWANSEA 1, MANCHESTER UNITED 3
Jose Mourinho was forced to watch from the stands as he served a touchline ban but he will have liked what he saw in south Wales.
There was a landmark goal for one of the brashest of players. The first of Zlatan Ibrahimovic's two goals was the 25,000th in the Premier League since the competition's inception in 1992.
Paul Pogba also unleashed a 20-yard volley for his second league goal since joining United in August from Juventus for a world-record fee of 105 million euros.
Swansea is only off the bottom due to Sunderland having an inferior goal difference and Bob Bradley has collected only one point from his first four matches in charge.
Bradley, the first American manager in the Premier League, has extend the winless run, which started under the fired Francesco Guidolin to 10 matches. That's the worst since Swansea was promoted to the Premier League in 2011.
ARSENAL 1, TOTTENHAM 1
Harry Kane made a scoring return from injury Sunday, grabbing the equalizer at Arsenal to preserve Tottenham's unbeaten start.
Kane, who has missed 10 games after damaging ligaments in his right ankle, converted a penalty six minutes into the second half to prevent Arsenal going top of the table.
In a north London derby played at a frantic pace, Tottenham gifted Arsenal the lead just before halftime when Kevin Wimmer inadvertently headed Mesut Ozil's free kick into his own goal.
Despite Spurs being on their longest unbeaten run in the league — 11 games — in more than 50 years they remain fifth.