ORCHARD PARK, N.Y. (AP) The Buffalo Bills look to be short-handed on offense in a pivotal divisional matchup against the New England Patriots.

Bills running back LeSean McCoy (hamstring) is doubtful and not expected to play. Wide receiver Robert Woods (foot) is questionable, and receiver Marquise Goodwin (concussion) is out.

Buffalo (4-3) is home against New England (6-1) at 1 p.m. on Sunday.

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McCoy has not practiced all week due to a hamstring injury. He originally injured the hamstring on Oct. 19, leading up to Buffalo's Week 6 game against Miami before suffering a setback against the Dolphins.

''Obviously, he never practiced so you can guys can figure that out,'' Bills coach Rex Ryan said.

McCoy has been the driving force on offense for the Bills this season. He is fourth in the league in rushing with 598 yards and six touchdowns.

Backup Mike Gillislee is expected to start in place of McCoy. Gillislee is questionable with a foot injury but expected to play. He's performed well with limited reps and had a 44-yard touchdown against San Francisco in Week 6.

Woods missed Buffalo's game against Miami and has been limited throughout the week. Buffalo is already without top receiver Sammy Watkins, who is on injured reserve. Goodwin suffered a concussion in Buffalo's loss to Miami.

''I'm still going day by day, trying to do everything possible to be out there Sunday,'' Woods said. ''We've still got some time before the game, so we'll see.''

Bills defensive tackle Marcell Dareus is expected to make his season debut against New England. Dareus missed the first four games of the year because of a suspension and injured his hamstring, which kept him out of the past two games.

Safety Aaron Williams (neck) is out.

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