CHARLOTTE, N.C. (AP) Carolina Panthers quarterback Cam Newton has been ruled out for Monday night's game against the Tampa Bay Buccaneers with a concussion.

The league's MVP hasn't practiced since taking a helmet-to-helmet hit in Sunday's 48-33 loss to the Atlanta Falcons.

Derek Anderson will start for Carolina in Newton's place.

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It's unclear when Newton will return. The Panthers visit the New Orleans Saints on Oct. 16 and then have a bye the following week.

Carolina will also be without three other starters on Monday - running back Jonathan Stewart (hamstring), left tackle Michael Oher (concussion) and cornerback James Bradberry (toe). Defensive tackle Vernon Butler (ankle), the team's first-round draft pick, is also out.

Outside linebacker Thomas Davis (hamstring), defensive end Charles Johnson (quad) and fullback Mike Tolbert (hamstring) are listed as questionable.