Britain's vote to leave the European Union has put everyone on alert.

Not the least of which is the NFL, which has been invested in extending its global reach since it held its first game in England as part of the International Series in 2007.

The league has three London-area games scheduled for the 2016 NFL season: a Week 4 matchup between the Jacksonville Jaguars and the Indianapolis Colts, the New York Giants vs. the Los Angeles Rams in Week 7, and the Washington Redskins vs. the Cincinnati Bengals in Week 8.

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So an NFL spokesman informed ProFootballTalk that the league was keeping close tabs on the situation.

"We are monitoring and have been in contact with our UK office," league spokesman Brian McCarthy told PFT in an email. "We head into the 2016 season in strong shape with the 3 UK games already nearing sell outs again -- a testament to the strong and passionate fan base there -- and all key media, sponsorship and licensing partnerships locked in."

How the NFL's relationship with Great Britain plays out beyond this season remains to be seen.