Ryan Garbutt scored the go-ahead goal in the second period for the Ducks, who beat the Nashville Predators 5-2 on Saturday for the first win by a home team in their first-round series, which Anaheim leads 3-2.
Nashville had won the first two games in Anaheim before the Ducks tied it with two wins on the Predators' home ice.
David Perron scored the tying goal earlier in the second and assisted on Garbutt's goal along with Ryan Getzlaf.
The Ducks added three goals in the third. Sami Vatanen scored on a breakaway, Cam Fowler had a power-play goal and Ryan Kesler added an empty-netter.
Frederik Andersen stopped 27 shots for the Ducks.
Game 6 is Monday in Nashville.