PHOENIX (AP) Arizona ace Zack Greinke got off to a rough start and lost again, with Kris Bryant and the Chicago Cubs beating the Diamondbacks 4-2 Saturday.

Greinke (0-2) gave up three runs in the first inning on four consecutive hits and a sacrifice fly.

Greinke signed a $206.5 million, six-year deal with the Diamondbacks as a free agent after going 19-3 with a 1.66 ERA for the Dodgers last season. Hit hard by Colorado on opening day earlier this week, the right-hander now has a 9.90 ERA.

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Bryant doubled twice and Ben Zobrist had three hits for the Cubs.

Kyle Hendricks (1-0) pitched four-hit ball into the seventh inning.

Hector Rondon earned his first save of the season with a scoreless ninth. That came after 1 1-3 hitless innings by Adam Warren.

Greinke has lost back-to-back starts for the first time since August 2014 with the Dodgers.

Greinke retired the leadoff batter before Jason Heyward, Zobrist and Anthony Rizzo singled and Bryant hit an RBI double. Miguel Montero followed with a sacrifice fly.

In six innings, Greinke gave up four runs and seven hits, striking out eight and walking three.

Zobrist doubled home Dexter Fowler in the fourth to give the Cubs a 4-0 lead. The Diamondbacks scored in the bottom half when Hendricks threw a wild pitch that allowed Chris Owings to score.

Brandon Drury hit an RBI double in the seventh.

Diamondbacks pitcher Rubby De La Rosa, who went 3 1/3 innings in a loss to the Cubs on Thursday, relieved in the eighth and struck out two in a hitless inning. It was his first relief appearance since Sept. 27, 2014, for Boston.

TRAINER'S ROOM

Cubs: OF-C Kyle Schwarber will return to Chicago to meet with team doctors when the Cubs leave Arizona after Sunday's game. He is out for the season after tearing ligaments in his left knee in an outfield collision with Fowler on Thursday night.

Diamondbacks: OF A.J. Pollock won't be able to start baseball activities for at least three months, a team doctor said Saturday. Pollock has a plate and several screws in his surgically repaired right elbow, which he broke in a preseason exhibition game April 1. ... P Josh Collmenter (right shoulder inflammation) had a slight setback in his return due to illness, but manager Chip Hale said his shoulder is feeling much better and he will throw bullpen sessions in the coming days.

UP NEXT

Cubs: Jake Arrieta looks for his second win of the season in as many starts. The 2015 NL Cy Young Award winner is 1-1 with a 2.61 ERA against Arizona in his career.

Diamondbacks: Shelby Miller (0-0) makes his second start as a Diamondback after a no-decision in his first. He's 1-2 with a 2.83 ERA in seven career games against the Cubs.