After their big-ticket addition flopped in his anticipated debut, the Arizona Diamondbacks are hoping for better results from their other newly acquired All-Star pitcher.

Shelby Miller hopes to make a better first impression as well with his new team when the Diamondbacks continue what's been a rough week in Tuesday night's game against the Colorado Rockies.

Chase Field went from buzzing to bummed in Monday's season opener after the Rockies knocked Zack Greinke around in the high-priced free agent's first start as a Diamondback. Greinke, signed to a club-record six-year, $206.5 million contract to anchor a revamped Arizona rotation, surrendered three homers - two to rookie Trevor Story - and seven runs over four disappointing innings of a 10-5 loss.

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Story, who hit .340 with six homers in the spring to win Colorado's starting shortstop job, became the first player in MLB history to homer twice while making his big league debut on opening day. The 23-year-old had a three-run shot during a six-run third inning and a solo blast in the fourth.

''It is unbelievable,'' Story said. ''It is something you don't even dream of or something that I never dreamed of. It is a really, really special moment.''

Carlos Gonzalez also homered off Greinke and Nolan Arenado added a three-run shot later on for Colorado, which dropped eight of 10 at Arizona during a 94-loss 2015 campaign.

The Diamondbacks, a trendy sleeper pick as a playoff contender following the offseason pickups of Greinke and Miller, lost its third straight opener three days after leadoff hitter and Gold Glove center fielder A.J. Pollock fractured his right elbow in a spring training game.

Miller will attempt to reverse Arizona's recent misfortune as well as turn around his own string of bad luck. Receiving the lowest run support in the majors, the right-hander went 6-17 for Atlanta during a 2015 season in which he lost 16 consecutive decisions over a 24-start stretch.

That ghastly record belied Miller's actual performance. The 25-year-old posted a 3.02 ERA and 21 quality starts and earned his first All-Star appearance.

The Diamondbacks paid a high price to get him, trading 2015 No. 1 overall pick Dansby Swanson, speedy outfielder Ender Inciarte and well-regarded pitching prospect Aaron Blair to the Braves in December.

Miller looks to improve on his lone career start at Chase Field, where he walked six and permitted four runs over 4 1-3 innings last June.

Chad Bettis draws the assignment for Colorado and aims to build off an encouraging first year as a full-time starter. After recording a 6.88 ERA in 37 appearances primarily as a reliever over his initial two seasons, the 26-year-old finished 8-6 with a 4.23 ERA in 20 starts as one of the few positives on a mostly dismal pitching staff.

Bettis was dealt a loss at Chase Field in his final 2015 outing despite allowing one earned run over six innings of a 3-1 defeat on Sept. 30. He yielded four runs and 11 hits through six innings against Arizona Aug. 31 in Colorado.

David Peralta is 4 for 5 against Bettis and collected three hits in the opener. Jake Lamb had a two-run homer for Arizona and Yasmany Tomas went 2 for 4 with two RBIs.

"The home runs will come," Tomas said. "My main focus is driving in runs and helping the teams win. The ball will go over the fence if you hit the ball hard and I'm just trying to hit the ball hard. Singles and doubles with runners on base are good, too. I'm just happy when we score."