Filip Forsberg recorded his second hat trick in four days and Pekka Rinne posted a 26-save shutout in Nashville's 5-0 win over St. Louis on Saturday.
Forsberg scored three goals during a 14-minute span to start the second period, leading the Predators to their fourth straight win.
Forsberg has a team-high 26 goals this season, including 12 in February. The left winger from Sweden posted his first career hat trick in Tuesday's 3-2 win at Toronto.
Linemate Craig Smith scored the Predators' first goal and Colin Wilson scored the fifth. Predators center Mike Ribeiro posted three assists, giving the playmaker 36 for the season.
Rinne became the fifth active goalie to record 40 career shutouts. A Vezina Trophy finalist last season, the Finnish goalie is 4-0-1 in his last five starts.
The Blues suffered their third consecutive defeat. Goaltender Jake Allen allowed five goals on 29 shots.