Anquan Boldin has missed the last two games with a hamstring injury. Wesley Hitt Getty Images

San Francisco 49ers running back Carlos Hyde did not practice again Wednesday in advance of Sunday's matchup at the Seattle Seahawks.

Hyde, the team's leading rusher, has not played or practiced since rushing for 40 yards on 11 carries in a 20-3 loss to the Seahawks on Oct. 22 due to a stress fracture in his foot.

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San Francisco first-year coach Jim Tomsula told reporters earlier Wednesday that Hyde would be available to practice. If Hyde is unable to play Sunday, the 49ers will go with a backfield of Shaun Draughn, Kendall Gaskins and Travaris Cadet. Neither of those players were on San Francisco's active roster in last month's meeting.

Wide receiver Anquan Boldin, who has missed the past two games with a hamstring injury, returned to practice Wednesday on a limited basis. Boldin also hasn't played since catching three passes for 39 yards in the loss to the Seahawks.

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