Injuries knocked Philadelphia quarterback Sam Bradford out of the game Sunday, and forced a hobbled Ben Roethlisberger off the bench for Pittsburgh.

Bradford trudged off the field with what appeared to be a left shoulder injury, and ended up with a concussion to boot, after a hard hit by Miami linebacker Chris McCain on a sack that forced a fumble.

Although X-rays were negative, Bradford held his non-throwing arm close to his stomach like it was in a sling after the third-quarter hit. Mark Sanchez took over for the first time this season in the Dolphins' 20-19 win.

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Eagles running back Ryan Mathews also left with a concussion. The Dolphins lost linebacker Jelani Jenkins (ankle) and cornerback Brice McCain (knee) during the game.

Roethlisberger, questionable with a sprained left foot, tossed three touchdown passes in a 30-9 win over Cleveland after Landry Jones left with a sprained left ankle.

Roethlisberger was limited in practice all week after getting hurt in last week's win over Oakland. The Steelers were encouraged enough to put their franchise quarterback in uniform against the Browns but started Jones anyway, figuring Jones would be more than effective against a Browns defense ranked last against the run and missing three starters in the secondary.

Jones never really got a chance. The second start of his career - all in the past three games - lasted all of seven snaps.

Jones turned his left ankle while throwing incomplete early in the first quarter and Roethlisberger - wearing a specially padded cleat to protect his bum foot - entered to a roar of a capacity crowd.

Julian Edelman, New England's leading receiver, sustained a foot injury in the first half against the New York Giants. He had four catches for 53 yards before the injury, which was announced with no indication of when Edelman got hurt.

Tennessee was already thin in the secondary with starting cornerbacks Perrish Cox and Jason McCourty inactive. Then, Bidi Wreh-Wilson, who started for Cox, left early in the second half with a hamstring injury.

Titans receiver Justin Hunter was carted off the field with an apparent right ankle injury late in a 27-10 loss to Carolina.

Rams rookie right Jamon Brown could be out for the season with a right foot injury.

New Orleans cornerback Keen Lewis went out after injuring his left knee.

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