LONDON (AP) Alex Smith threw for 145 yards and two touchdowns, and ran for 78 yards and another TD to lead Kansas City over the Detroit Lions 45-10 Sunday at Wembley Stadium.

Smith scrambled his way through the Detroit defense for some big plays, including a career-high 49-yard run in the second quarter that set up his 12-yard touchdown run.

The Chiefs (3-5) were at Wembley for the first time, while the Lions (1-7) played in London for the second straight season.

More from FoxSports

De'Anthony Thomas, Charcandrick West and Spencer Ware also rushed for touchdowns for the Chiefs. Thomas ended up with 100 total yards, while West ran for 97. Travis Kelce and Jeremy Maclin caught TD passes in the second half.

The Lions were playing for the first time since offensive coordinator Jim Bob Cooter took over for the fired Joe Lombardi. And although the offense got moving on the opening possession, it stalled horribly after that.

Matthew Stafford threw for 217 yards, one touchdown and two interceptions. Also, Calvin Johnson had 85 receiving yards, while Joique Bell ran for 56. But after the Lions took a 3-0 lead on 35-yard field goal from Matt Prater, Detroit was hapless with the ball.

---

Online:

AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFL