Sammy Watkins ended Sunday's first half by scoring a touchdown but injured his ankle in the process.
The Bills wide receiver, who asked for more targets earlier this week, limped off the field, and the broadcast showed him on crutches. He was later ruled out for the entire game.
Watkins sustained a sprained ankled, according to NFL Media's Ian Rapoport.
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Watkins missed last week's game with a calf injury and has been hampered by injuries all season. The No. 4 pick in last year's draft entered Sunday's game with just seven catches for 99 yards.