SAN FRANCISCO (1-3) at NEW YORK GIANTS (2-2)

Sunday, 8:30 p.m. ET, NBC

OPENING LINE - Giants by 7

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RECORD VS. SPREAD - 49ers 1-3, Giants 3-1

SERIES RECORD - Series tied 19-19

LAST MEETING - 49ers beat Giants 16-10, Nov. 16, 2014

LAST WEEK - 49ers lost to Packers 17-3; Giants beats Bills 24-10

AP PRO32 RANKING - 49ers No. 31, Giants No. 12

49ers OFFENSE - OVERALL (31), RUSH (5), PASS (32).

49ers DEFENSE - OVERALL (23), RUSH (20), PASS (21).

GIANTS OFFENSE - OVERALL (22), RUSH (24), PASS (19).

GIANTS DEFENSE - OVERALL (26), RUSH (1), PASS (32).

STREAKS, STATS AND NOTES - All that separates teams after 38 games is 14 points in Giants favor. ... 49ers QB Colin Kaepernick is 2-1 against Giants. ... After running for 168 yards in season opener, halfback Carlos Hyde has 114 yards in last three games. ... Since 2011, WR Torrey Smith is second in NFL with 17-yard average, minimum of 200 catches. ... WR Anquan Boldin leads team with 15 catches for 124 yards. Smith leads in receiving yards with 185. ... LB Aaron Lynch had two sacks last week and leads team with three. ... San Francisco is last in NFC with minus-5 differential on turnovers. ... Giants QB Eli Manning is 5-2 against Niners, including playoffs. ... Giants have not rushed for 100 yards in game this season. ... WR Odell Beckham Jr. is tied for 18th in league with 24 catches. He is tied for 11th on third downs with eight for 102 yards. ... WR Rueben Randle has caught touchdown pass in each of last two games. ... CB Prince Amukamara leads team with six passes defended. ... Uani Unga has two interceptions, tied for league lead among linebackers. ... Giants are tied for second in turnover differential at plus 6. ... Fantasy Tip: While Manning has one interception this season, 49ers had five picks against him last year.

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AP NFL website: www.pro32.ap.org and www.twitter.com/AP-NFL