Now the Dallas Cowboys have to defend their NFC East title without Tony Romo, Dez Bryant and DeMarco Murray.
Romo joined Bryant on the injured list with a broken left collarbone, but the Cowboys shut down Murray and beat the Philadelphia Eagles 20-10 on Sunday.
Romo, who missed 10 games with a similar injury in 2010, will be evaluated Monday. Bryant will miss at least six weeks after having foot surgery. Murray plays for Philadelphia, though he probably wishes he never left Dallas.
"The NFL really is about adversity," Romo said. "It's about how you handle it, how you approach it individually and collectively as a team."
The Cowboys (2-0) passed a tough test.
Kyle Wilber returned a blocked punt 26 yards for touchdown, Brandon Weeden threw a 42-yard touchdown pass to Terrance Williams and the Cowboys overcame a franchise-record 18 penalties in their 10th consecutive road win.
"Whenever you have a coaching staff that doesn't panic, the players see it's not as bad as things seem," Williams said.
The Eagles (0-2) were favorites to take the division title away from Dallas, but they look more like a team that will contend for the top pick in the draft than the playoffs.
Murray, the reigning NFL rushing champion, had 2 yards rushing on 13 carries in his first game against his former team. Sam Bradford had three turnovers, including an interception in the end zone. Philadelphia had 21 total yards in the first half and finished with 226.
"All I'm worried about is winning," Murray said. "I'm not worried about rushing yards or touchdowns. We have to find a way to get it done. It's as simple as that."
Romo was knocked out of the game in the third quarter when Jordan Hicks sacked him. Fletcher Cox recovered Romo's fumble and Bradford drove the offense to the Cowboys 3 before Sean Lee intercepted his pass in the end zone.
"I'll be back," Romo said. "It's going to take a little bit of time. It's a broken bone. It is what it is."