BOSTON (AP) Designated hitter David Ortiz has been replaced by a pinch hitter in the fifth inning of Boston's game against Philadelphia.

There was no immediate word on why Ortiz left Sunday's game.

The 39-year-old slugger connected for a two-run shot against Jerad Eickhoff in the first, lifting the Red Sox to a 2-0 lead. It was his 200th homer at Fenway Park and No. 497 for his career overall.

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Ortiz added a sacrifice fly in the second.