Juventus had two men sent off as their dismal start to the Serie A season continued at Roma.
The champions, who lost their opening match at home to Udinese last week, went down 2-1 at the Stadio Olimpico and had Rubinho and Patrice Evra sent off in the final quarter.
Miralem Pjanic opened the scoring for Roma with an impressive free-kick just past the hour mark and, after their opponents had been reduced to nine men, Edin Dzeko headed home with 11 minutes remaining to double the advantage.
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Paulo Dybala pulled a goal back in the 88th minute and the visitors launched a belated battle for an unlikely point. However, it did not come and Juve, who won the league by 17 points last season, find themselves without a point from their first two games of this campaign.