CLEVELAND (AP) Jason Kipnis homered and drove in three runs, and the Cleveland Indians used six pitchers in a 6-2 win over the Milwaukee Brewers on Wednesday night.

Kipnis, who leads the American League with a .325 batting average, gave Cleveland the lead with a two-run double with the bases loaded in the second inning. He added a solo homer in the eighth.

Rookie right-hander Cody Anderson, starting in place of the injured Carlos Carrasco, allowed two runs in 4 1/3 innings. Carrasco, who leads the Indians in wins, was placed on the 15-day disabled list Wednesday with a sore right shoulder.

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Jeff Manship (1-0) worked 1 1/3 innings for his first win since April 26, 2014, when he was pitching for Philadelphia against Arizona.

Jimmy Nelson (10-10) allowed five runs and walked eight in 3 1/3 innings in losing for the first time since July 10.

Rookie Francisco Lindor stole three bases and Lonnie Chisenhall added an RBI for the Indians, who have won six of seven at home.

Anderson pitched for the first time since Aug. 7, when he was sidelined with a strained left oblique. He was scheduled to begin a minor league rehab assignment Monday for Single-A Lake County, but was scratched when the Indians decided to shut down Carrasco.

Khris Davis hit a leadoff homer in the second, but Anderson retired the next 10 hitters. He was pulled after allowing a walk and a single in the fifth, throwing 75 pitches.

Cleveland answered Davis' homer with a three-run second. Abraham Almonte's single and walks to Jerry Sands and Jose Ramirez loaded the bases. Kipnis lined a hit over third base, scoring Almonte and Sands. Ramirez scored when Davis booted the ball, which rolled to the corner.

TRAINER'S ROOM

Brewers: RHP Tyler Cravy (right elbow impingement), who has been on the DL since Aug. 19, participated in a plyometric workout Wednesday. He is expected to resume throwing within a week.

Indians: RHP Gavin Floyd (right elbow fracture) will begin a minor league rehab assignment Saturday at Double-A Akron. He was injured in spring training.

UP NEXT

Brewers: RHP Taylor Jungmann seeks his second victory over the Reds when the teams begin a three-game series Friday in Milwaukee.

Indians: RHP Danny Salazar will start the opener of a three-game home series Friday against the Angels.