KANSAS CITY, Mo. (AP) Omar Infante led a seven-run charge in the sixth inning to support a strong start by Kris Medlen, helping the Kansas City Royals beat the Baltimore Orioles 8-3 on Monday night.

Despite working on a pitch count, Medlen (2-0) lasted six innings in his first start since Sept. 27, 2013, with Atlanta. The right-hander allowed five hits - one of them a two-run homer by Adam Jones in the first inning - while striking out six without a walk.

Medlen, who returned last month after his second Tommy John surgery, made seven appearances out of the Kansas City bullpen before replacing Jeremy Guthrie in the starting rotation.

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Infante followed a tying, two-run homer by Mike Moustakas in the sixth with a two-run triple, then scampered home when the throw to third base skittered away. Lorenzo Cain drove in two more later in the inning, spoiling what had been a promising start by Ubaldo Jimenez.

Jimenez (9-8) allowed seven runs and 10 hits in 5 2-3 innings.

The loss was the fifth straight for Baltimore and sixth in seven games. It carried a little added sting in that it was the first meeting between the teams since the Royals swept the Orioles in the AL Championship Series on their surprising run to the World Series.

The two-run homer by Jones and a run-scoring double by Steve Clevenger in the fourth inning got the Orioles off to a good start, and Jimenez was cruising through five. The only run he had allowed was on an RBI groundout by Eric Hosmer in the third inning.

Things finally unraveled for Jimenez in the sixth.

Hosmer doubled with one out and Moustakas sent a pitch soaring into the right-field stands to knot the game 3-all. Salvador Perez singled, Alex Rios hit a double and Infante sent a triple into the gap in left-center, sliding into third base ahead of the throw. When it skipped away to the third-base dugout, Infante clambered to his feet and chugged on home.

Alcides Escobar and Ben Zobrist followed with hits before Cain's two-run double made it a seven-run inning, matching a season best for the Royals.

Medlen's night was done by that point. He threw 69 pitches, one fewer than manager Ned Yost had said was his limit. Bullpen buddies Franklin Morales and Luke Hochevar did the reset.

TRAINER'S ROOM

Orioles: SS J.J. Hardy (groin) went on the DL and INF-OF Steve Pearce (left oblique) was reinstated. ... RHP Mike Wright (calf) will start for Triple-A Norfolk on Thursday.

Royals: First base coach Rusty Kuntz was back at work after missing 13 days with a sinus infection and stomach virus. Kuntz said he lost more than 10 pounds during the illness.

UP NEXT

Orioles: RHP Miguel Gonzalez tries to bounce back from an awful start against Minnesota in which he allowed seven runs in five innings of a 15-2 rout.

Royals: LHP Danny Duffy has dominated the Orioles in three career outings, going 1-1 with a 1.46 ERA. Last May, he retired the first 20 batters he faced.