BOSTON (AP) -- David Ortiz hit his 492nd career homer, Jackie Bradley Jr. and Ryan Hanigan connected on consecutive pitches, and Joe Kelly went six strong innings to lead the Boston Red Sox to a 6-4 win over the Cleveland Indians on Wednesday night.

Travis Shaw also homered following Ortiz's solo shot for the Red Sox, who have won four of six.

The victory came a day after the Red Sox shook up their front office, hiring Dave Dombrowski as president of baseball operations. General manager Ben Cherington declined to stay after he helps with the transition.

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Boston's homers all came off Corey Kluber (8-13), last season's AL Cy Young Award winner.

Yan Gomes hit a three-run shot for the Indians, who have lost four of five.

Kelly (6-6) gave up one unearned run on five hits, striking out three and walking three to win his fourth straight start. Junichi Tazawa worked the ninth for his first save.

Leading 2-0 in the fourth, Bradley hit a three-run homer off the base of a light stanchion above the Green Monster. The ball caromed onto the field while Bradley was scampering around second on a relay throw home before the umpires could get the players' attention.

Hanigan followed by hitting his completely out of Fenway Park, clearing the Monster seats to make it 6-0.

Kluber gave up six runs in six innings, striking out nine and walking one. He was coming off a one-hit complete game in his previous start Friday against Minnesota.

Bradley also made a nice over-the-shoulder catch in full stride.

Ortiz and Shaw homered in the second. Ortiz's sailed into Cleveland's bullpen just beyond the reach of right fielder Lonnie Chisenhall.