Rome, Italy (SportsNetwork.com) - Red-hot Andy Murray and seven-time champion Rafael Nadal notched second-round victories Wednesday at the $4.335 million Italian Open tennis event.

The third-seeded Murray improved to 10-0 on clay this year by cruising past Frenchman Jeremy Chardy 6-4, 6-3, while the fourth-seeded former world No. 1 Nadal whipped Turkish qualifier Marsel Ilhan 6-2, 6-0 at Foro Italico.

"My legs were a bit tired at the beginning," Murray said after beating Chardy. "But then I started to feel better after the first few games. For me, I felt like I played a really good match."

Chardy helped Murray's cause with 26 unforced errors.

Murray beat Nadal in last week's Madrid Masters final to capture his second clay-court title in two weeks -- the first two clay titles of his career.

The French Open king Nadal lost to three-time champ Novak Djokovic in last year's Rome finale. The two greats have combined to win the last 10 titles at this Masters 1000 tournament.

Meanwhile, fifth-seeded U.S. Open runner-up Kei Nishikori handled Czech Jiri Vesely 7-6 (7-3), 7-5.

Upsets came when Italy's own Fabio Fognini toppled 10th-seeded Bulgarian Grigor Dimitrov 7-6 (11-9), 4-6, 6-0, Austrian Dominic Thiem tackled 12th- seeded Frenchman Gilles Simon 7-6 (7-5), 2-0, retired, and Brazilian qualifier Thomaz Bellucci overcame 14th-seeded Spaniard Roberto Bautista Agut 1-6, 6-1, 6-4. Bellucci will meet the current world No. 1 and reigning Rome champ Djokovic on Thursday.

Also on Day 3, 16th-seeded American John Isner topped Argentine Leonardo Mayer 7-6 (8-6), 6-4 and Spaniard Guillermo Garcia-Lopez dismissed Ukrainian qualifier Alexandr Dolgopolov 6-4, 6-3. Isner is rewarded with a third-round match against the clay-court wizard Nadal.