(SportsNetwork.com) - The Cincinnati Reds will begin the final stretch of their 10-game road trip with Friday's opener of a three-game series against the Chicago White Sox at U.S. Cellular Field.

The Reds are 4-3 on the trek and failed in their bid of a three-game sweep of the Pittsburgh Pirates with Thursday's 7-2 loss. Todd Frazier homered for the 10th time this season and starting pitcher Anthony DeSclafani was dealt the loss for allowing three runs and seven hits in five innings.

"I was fighting myself," said DeSclafani. "I definitely wasn't happy with this outing. I wasn't getting ahead of hitters at all. I've got to figure something out and make changes ASAP."

DeSclafani walked four and struck out one.

It didn't help that the Reds went 0-for-6 with runners in scoring position and stranded seven.

Jason Marquis will take the mound for Cincinnati Friday and has won his last three starts. He is 3-1 with a 5.22 earned run average in five outings and gave up three runs over 6 1/3 innings in Saturday's 8-4 win at Atlanta.

Marquis has made four career starts against the White Sox, going 2-1 with a less-than-stellar 9.00 ERA.

The White Sox took two of three from the Detroit Tigers and were denied a sweep with Thursday's 4-1 loss.

Avisail Garcia drove in Chicago's lone run and Jose Quintana fell to 1-3 on the mound after surrendered two runs in five innings. He struck out eight and walked two batters.

"They did a pretty good job of batting deep in their at-bats, not giving in," White Sox catcher Tyler Flowers said of the Tigers. "They fouled off a lot of well-executed pitches and forced you to throw multiple instead of getting them out on the first one."

Chicago has lost six of its last eight games and will hand the ball to Hector Noesi Friday night. Noesi is winless (0-3) on the season and has a 6.75 ERA. He allowed five runs in 4 1/3 innings of a 5-3 loss at Minnesota on Saturday and has faced the Reds once before in relief.

The White and Reds are meeting for the first time since 2009, when Chicago took two of three matchups in the Queen City.