Chennai, India (SportsNetwork.com) - The season-opening Chennai Open lost its second seed on Thursday when Feliciano Lopez succumbed to Slovenian qualifier Aljaz Bedene, 6-4, 6-4.

Three other seeds avoided upsets, as No. 3 Spaniard and 2013 runner-up Roberto Bautista Agut handled German Peter Gojowczyk 6-3, 6-2, No. 5 Spaniard Guillermo Garcia-Lopez overcame Japan's Tatsuma Ito 6-7 (1-7), 6-2, 6-0 and No. 6 Yen-Hsun Lu of Taiwan got past Spain's Pablo Carreno Busta 6-4, 6-4 on the hardcourts at SDAT Tennis Stadium.

Friday's quarterfinals will pit top-seeded and defending champion Stan Wawrinka against eighth-seeded Gilles Muller of Luxembourg; Bautista Agut versus Lu; fourth-seeded Belgian David Goffin against Austrian Andreas Haider- Maurer; and Garcia-Lopez versus Bedene.

The two-time Chennai champ Wawrinka, who also titled here in 2011 and was the runner-up in 2010, beat Frenchman Edouard Roger-Vasselin in last year's finale.

Chennai serves as a tune-up for the Australian Open, where Wawrinka is also the reigning titlist.