Updated

Berea, OH (SportsNetwork.com) - Johnny Football's rookie season is over.

Cleveland Browns quarterback Johnny Manziel will miss Sunday's finale against Baltimore with what his coach said Monday is a "pretty significant" hamstring injury.

Manziel was hurt on a scramble in the final minutes of the first half Sunday when he was hit by two Carolina players while going out of bounds.

The first-round draft pick was replaced by Brian Hoyer, whose status for this weekend's game is up in the air after he suffered a shoulder injury against the Panthers.

The injuries have left Browns coach Mike Pettine uncertain of who will start at quarterback against the Ravens.

Undrafted rookie Connor Shaw will see more reps in practice this week but Pettine said on a conference call Monday he hasn't ruled out other options, according to the team's official website.

Manziel struggled after replacing Hoyer to make his first NFL start against Cincinnati last week and didn't fare much better in four series against the Panthers on Sunday.

He completed 13 of 26 passes in the two starts for 112 yards, no touchdowns and two interceptions.

The Browns (7-8) have lost four games in a row but will finish with their best record since going 10-6 in 2007.