SMU quarterback Matt Davis ran for 191 yards and a touchdown and threw for another 145 yards to lead the Mustangs to their only win of the season, 27-20 over UConn.
Prescott Line added 90 yards rushing and two second-half touchdowns as SMU (1-11, 1-7 American Athletic Conference) snapped a 13-game losing streak.
Freshman Ron Johnson ran for 101 yard and a touchdown for UConn (2-10, 1-7), which finishes tied with SMU for last place in the conference.
UConn led 20-6 at the half, but SMU scored 21 unanswered points after the Huskies fumbled the second half kickoff, one of five UConn turnovers.
Line scored on a 4-yard run four plays later. His 12-yard touchdown in the fourth quarter was the game winner, capping an 8-play 70 yard drive that included a 48-yard run by Davis.
Darius Joseph caught nine passes for 108 yards for SMU.