Northwestern linebacker Jimmy Hall set up 14 points with an interception and a fumble recovery, and the Wildcats beat Purdue 38-14 on Saturday.
A victory against Illinois on Nov. 29 would make the Wildcats (5-6, 3-4 Big Ten) bowl eligible.
Wildcat quarterback Trevor Siemian hurt his left leg trying to pick up a first down and did not return. He was replaced by Zach Oliver.
Hall's interception of a pass by Austin Appleby — one of four first-half Purdue turnovers — set up Northwestern's first score, a 24-yard pass from Siemian to Dan Vitale.
Hall recovered a fumble by Akeem Hunt at the Northwestern 43, setting up a nine-play, 57-yard drive, capped by Justin Jackson's 9-yard touchdown run for a 14-0 lead.
Jackson finished with 23 carries for 147 yards and two touchdowns.
Purdue (3-8, 1-6) has yet to win a Big Ten home game in coach Darrell Hazell's two seasons, falling to 0-8.