Kevin Pangos made five 3-pointers and scored 17 points as No. 13 Gonzaga shut down No. 22 SMU 72-56 on Monday night.
Domantas Sabonis added 13 points for Gonzaga (2-0) whose defense especially stymied the Mustangs in the second half.
Ben Moore scored 11 points and Nic Moore 10 for SMU (1-1), which is in its third season under Hall of Fame coach Larry Brown.
This was the first meeting between the programs.
The Mustangs shot just 31 percent, making 19 of 61 shots. They shot just 24 percent in the second half.
Gonzaga, which scored 104 points in its season opening win over Sacramento State, shot a modest 45 percent against SMU.
Gonzaga led by 10 at halftime, and maintained that lead in the early going of the second half behind a pair of 3-pointers by Pangos, who also had seven assists.