Carson Palmer had three touchdown passes after an early interception the Cowboys returned for a score, and the Dallas offense struggled without the injured Tony Romo in a 28-17 loss to Arizona on Sunday.
The Cardinals (7-1), who have sole possession of the best record in the NFC for the first time since 1974, won their fourth straight. They have beaten all five conference opponents.
Romo was out with his third back injury in 18 months, and backup Brandon Weeden threw two interceptions as the Cowboys (6-3) dropped their second straight after a six-game winning streak.
NFL rushing leader DeMarco Murray's record streak of eight straight 100-yard games to start the season for Dallas ended against a defense that didn't allow a back over the century mark for the 18th consecutive time. He rushed for 79 yards on 19 carries.
AP NFL website: www.pro32.ap.org and www.twitter.com/AP_NFL