Brandon Radcliff ran for 110 yards and two touchdowns, and Louisville had two interceptions and two safeties in a 28-6 victory over Syracuse on Friday night, the Orange's third straight loss.

The Cardinals (5-1, 3-1 Atlantic Coast Conference) moved to 4-0 against Syracuse under Bobby Petrino. With a grueling schedule ahead, Syracuse (2-3, 0-1 ACC) began ACC play with a thud, getting just a pair of field goals from Cole Murphy, one in each half.

Entering the game, the series was tied 6-6, the Orange evening the count two years ago in the Carrier Dome when the teams were Big East members. Syracuse rolled to a 45-26 victory over the Teddy Bridgewater-led Cardinals to snap a three-game losing streak in the series. It was No. 11 Louisville's first loss that season after nine wins and served as motivation for the Cardinals coming into Friday night.