More than a month into the season, Syracuse finally gets a taste of Atlantic Coast Conference action, and there might be no better opponent for the Orange to face than Louisville.

Riding a two-game losing streak and with a grueling schedule ahead, Syracuse (2-2) begins ACC play on Friday night at home against the Cardinals (4-1, 2-1 ACC), who have been knocked for a loop more than once by the Orange in the past seven years.

The series is tied 6-6, but the Orange have dominated of late. In Louisville's last trip to the Carrier Dome two years ago, Ryan Nassib passed for 246 yards and three TDs in a 45-26 Syracuse victory over the Teddy Bridgewater-led Cardinals. It was the first loss of the season after nine wins for 11th-ranked Louisville.