Quarterback Trevone Boykin threw for four touchdowns and ran for two others Saturday and TCU smothered struggling SMU 56-0.
The victory was the most lopsided in the series' 94-game history.
Boykin threw scoring passes of 28 and 7 yards to Deante Gray, 6 yards to Josh Doctson and 10 yards to Desmon White. He ran for touchdowns of 27 and 8 yards.
B.J. Catalon added a 9-yard touchdown run, and backup quarterback Matt Joeckel threw a 25-yard touchdown pass to Charlie Reid for TCU (3-0).
SMU (0-4) failed to score for the second time this season. The Mustangs drove to TCU's 3-yard line in the waning seconds, and reserve quarterback Matt Davis was sacked on the final play.
SMU's only touchdown to date is a 33-yard hail Mary pass on the final play at North Texas on Sept. 6.