Louisville coach Bobby Petrino has announced that freshman Reggie Bonnafon will make his first start at quarterback on Saturday against Wake Forest in place of injured sophomore Will Gardner.

Petrino made the announcement after Thursday's practice and said that Gardner "has responded well to treatment" but wasn't cleared by the medical staff to play.

Gardner injured his knee in the third quarter of last week's 34-3 victory at Florida International, which Bonnafon missed to attend his father Wallace's funeral in Louisville.

Bonnafon returned to the team on Sunday and has worked out with the Cardinals (3-1, 0-1 Atlantic Coast Conference). He has played in two games as Gardner's backup and completed 14 of 20 passes for 151 yards and a touchdown. He has also rushed for two TDs.