Ryan Howard singled in the winning run with two outs in the bottom of the 15th inning to lift the Philadelphia Phillies to a 2-1 victory over the Houston Astros on Tuesday night.
The interleague matchup between teams with two of the four worst records in the majors lasted 5 hours, 5 minutes.
Hector Neris (1-0) tossed a perfect inning to earn the win in his major league debut.
Grady Sizemore led off the inning against Jake Buchanan (1-2) with a hard one-hop single under second baseman Jose Altuve's glove. After Ben Revere sacrificed, Jimmy Rollins flied out and Chase Utley was intentionally walked.
Howard then ripped a 1-2 pitch to right and Sizemore slid in safely ahead of right fielder Robbie Grossman's throw.
It was the fifth game of at least 14 innings for the Phillies this season, tying a franchise-record first set in 1958.
Both starters — Philadelphia's Kyle Kendrick and Houston's Dallas Keuchel — allowed one run in seven innings.
Howard led off the bottom of the second with an opposite-field homer that just cleared the wall in left-center, giving the Phillies a 1-0 lead. The run snapped a 22-inning scoreless streak for Philadelphia, which was shut out in Washington on Saturday and Sunday.
Howard's homer was his seventh off lefties in 97 at-bats. He has only 10 against right-handers in 308 at-bats. Howard, who faces an extreme shift to right in all of his at-bats, still hasn't pulled a homer.
Jon Singleton's RBI single in the seventh tied it at 1. The Astros had runners at first and third with no out, but couldn't get the go-ahead run. Matt Dominguez flied out to shallow right and Jake Marisnick grounded into a double play.
Astros: Outfielder George Springer, on the disabled list since July 20 with a strained left quad, made his second rehab appearance at Single-A Quad Cities. Springer could be called up before the series ends Thursday.
Phillies: Cliff Lee still hasn't had an MRI on his injured left elbow. ... Left fielder Domonic Brown has an infection in his tonsils and wasn't in the lineup for the fourth straight game. ...
Astros: Right-hander Brad Peacock (3-7, 4.93) will come up from Triple-A Oklahoma City to start Wednesday night. He's replacing Jarred Cosart, who was traded to Miami last week. Peacock gave up seven runs in 3 2-3 innings in his last start on July 23, a 9-7 loss at Oakland.
Phillies: Righty David Buchanan (5-5, 4.40) will be recalled from Triple-A Lehigh Valley to take Lee's spot. Buchanan has allowed three earned runs or less in his last six major-league starts