Former Duke and NBA star Grant Hill and his wife are giving $1.25 million to the school.
President Richard Brodhead announced the donation Wednesday.
He says $1 million will go to the athletic department with the remainder going to the school's annual fund in support of Trinity College.
Brodhead calls Hill "a beloved part of Duke's history."
The 1994 Atlantic Coast Conference player of the year led the Blue Devils to national championships in 1991 and '92, then made five All-Star teams during an 18-year NBA career.
Hill says he and his wife "are in a fortunate position to be able give back to the university that did so much for me."
They previously gave $1 million to establish a men's basketball scholarship fund.