Agnieszka Radwanska, the 2012 Wimbledon runner-up, lost in the fourth round to 22nd-seeded Ekaterina Makarova of Russia 6-3, 6-0 Monday.
Radwanska was a semifinalist at the All England Club in 2013 and was seeded fourth this year. Her exit means three of the tournament's four highest-seeded women are gone before the quarterfinals, joining No. 1 Serena Williams and No. 2 Li Na on the sideline.
Makarova is into the quarterfinals at Wimbledon for the first time, and now she will face 23rd-seeded Lucie Safarova of the Czech Republic.
Neither has ever been to a Grand Slam semifinal: Makarova is 0-3 in major quarterfinals; Safarova is 0-1.