David Toms, Hideki Matsuyama, Chad Campbell and Chris Stroud shared the third-round lead at 7-under 203 on Saturday at Colonial, where plenty of others also are in contention.
There were 13 players within two strokes of the leading quartet.
The closest chasers include Adam Scott, the No. 1 player in the world, and Jimmy Walker, a three-time winner this season and No. 1 in the FedEx Cup standings.
Kevin Chappell, whose early 7-under 63 was the low round of the day, moved from a tie for 60th to within one stroke of the lead.
Matsuyama, the 22-year-old from Japan with five wins at home, shot a bogey-free 64. Toms, who got the last of his 13 PGA Tour victories at Colonial in 2011, had a 65, and local resident Campbell shot a 68.