The Cincinnati Reds have still yet to win a regular season game in Boston.
They also have never beaten Jake Peavy, who takes the mound tonight for the Red Sox in the finale of a quick two-game series at Fenway Park.
The 32-year-old Peavy is 6-0 with a 2.14 earned run average in 10 career meetings with the Reds. Cincinnati has hit just .222 off the veteran over his career and Peavy has a WHIP of 1.04 with two complete games lifetime in this matchup.
Peavy is 1-1 with a 2.87 ERA on the season, picking up his first win of the season on April 25 with seven innings of one-run ball versus Toronto.
However, the righty followed up that victory with his first loss of 2014 as he dropped a 2-1 decision to the Tampa Bay Rays on Thursday. Peavy yielded both runs on three hits and five walks over 6 1/3 innings.
Boston won Tuesday's opener in extra innings, improving to 6-1 all-time versus Cincinnati in the regular season. The Red Sox swept a three-game set at home in 2005 before taking two of three in Cincinnati back in 2008.
The Reds, of course, beat the Red Sox in seven games to win the 1975 World Series, winning twice in four games at Fenway Park.
Cincinnati will try to pick up the rare win in Boston tonight behind Mike Leake, who has lost his last two starts but pitched well enough to win on Friday versus Milwaukee.
After having allowed 11 runs over his previous three outings, the right-handed Leake dropped a tough-luck 2-0 decision to the Brewers. He hurled eight innings of seven-hit ball, but the setback was made a bit more painful as the 26-year-old yielded both runs on a double by Brewers starter Wily Peralta in the fifth inning.
"You have to give credit to solid starting pitching from both pitchers," Reds manager Bryan Price said.
Leake is 2-3 with a 3.53 ERA on the season and faces Boston for the first time.
The Reds rallied to force extra innings last night before losing the one-run decision in 12 innings. David Ortiz led off the 12th frame for Boston with a single and then moved to second on Mike Napoli's base hit before Grady Sizemore's walk-off single to the base of the Green Monster got between Ryan Ludwick and Skip Schumaker.
Sizemore drove in two runs and finished with three hits to help Boston move to 4-3 on an eight-game homestand.
"Grady has gotten some consistent at-bats," said Red Sox manager John Farrell. "He went through a little bit of a stretch where there wasn't much to show for it, but a number of good swings over the last few swings. None bigger than to walk things off here tonight."
The Reds had tied the game with two runs in the eighth frame, but failed to extend their winning streak to three straight. Todd Frazier and Ludwick both drove in runs during the eighth frame.
Cincinnati was without outfielder Jay Bruce, who could miss up to a month of action following recent left knee surgery, while speedy center fielder and leadoff hitter Billy Hamilton has not started since Thursday due to a pair of sprained knuckles on his left hand. He remains day-to-day and has been limited to pinch-running duties.