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Isner loses to Brown in second round of US Men's Clay Court Championship

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Dustin Brown hits a return against John Isner at the U.S. Men's Clay Court Championship tennis tournament on Wednesday, April 9, 2014, in Houston. (AP Photo/Houston Chronicle, Bob Levey) MANDATORY CREDIT (The Associated Press)

Top-seeded John Isner lost to journeyman Dustin Brown in the second round of the U.S. Men's Clay Court Championship on Wednesday night.

It was Brown's first career victory against a top-10 player. He closed out a 6-4, 6-7 (7), 7-6 (4) win with a forehand approach winner.

Isner was the defending champion in Houston. He had 13 aces in the loss.

American Sam Querrey also advanced with a 6-3, 6-4 victory over No. 7 seed Lleyton Hewitt.

Sixth-seeded Juan Monaco beat Somdev Devvarman of India 7-6 (4), 6-2 for his 200th career win on clay.