Penalties increased from 50 games to 80 games for first performance-enhancing drugs testing violation and from 100 games to 162 (with loss of all 183 days' pay) for second violation. Penalties also increased from 50 to 80 games for first criminal conviction involving PEDs and from 100 games to 162 (with loss of all 183 days' pay) for second offense.
— An arbitrator will be allowed to reduce a suspension for a first or second testing violation by up to 50 percent if a player proves by "clear and convincing evidence" that a positive test was not caused by his "significant fault or negligence." However, penalties may not be cut for muscle-building substances such as testosterone, human growth hormone, Boldenone, Nandrolone, Stanozolol. Gonadotropins, Selective Estrogen Receptor Modulators and Anti-Estrogens.
— A player suspended for a PEDs violation whose discipline is not reduced for mitigating circumstances is not eligible to play in the postseason of the season in which the suspension began. The player also is ineligible to receive an automatic full share of the players' pool but may be voted a cash award by his teammates, subject to amount limitations.
— Increases in-season random urine tests from 1,400 to 3,200 anually, in addition to the 1,200 mandatory random urine tests during season and 1,200 during spring training. Offseason urine tests increased from 250 to 350.
— Increases random blood tests for human growth hormone to 400 annually, in addition to the 1,200 spring training blood tests
— Increased follow-up tests for previous PED violators to six additional unannounced urine tests and three additional unannounced blood tests for the remainder of the player's career, except for those whose suspensions have been reduced for mitigating circumstances.
— Carbon Isotope Ratio Mass Spectrometry tests of at least one urine sample per player each season.
— Foreign players entering the major leagues and any players not covered by major or minor league drug testing for at least one year are required to take a urine and blood test before signing contracts.
— Didehydroepiandrosterone (DHEA) is added to the banned list.
— Clubs to provide certified supplements to players year-round.
— Confidentiality provisions strengthened in a manner not specified.