Louisville finds itself one win away from returning home for a NCAA tournament regional.
The Cardinals will have to beat an Iowa team that can shoot the lights out in its own gym to get there.
Third-seeded Louisville (31-4) played more like a top seed in its 88-42 blowout of Idaho in the first round on Sunday. But Iowa looked nearly as good, shooting 57 percent in an 87-65 win over Marist that was a lot easier than most thought it would be.
The Cardinals and the sixth-seeded Hawkeyes (27-8) meet Tuesday in the second round in Iowa City. The winner will face LSU or West Virginia in Louisville on Sunday.